WebSep 17, 2024 · CRYBA2 crystallin beta A2 Gene ID: 1412, updated on 17-Sep-2024 Gene type: protein coding Also known as: CTRCT42 See all available tests in GTR for this … WebMammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they ...
Crystallin - Wikipedia
WebAug 7, 2014 · Aarts et al. (1987) isolated and characterized human and rat genomic clones containing sequences for beta-B2 crystallin (CRYBB2; 123620) and/or beta-B3 crystallin. Lampi et al. (1997) cloned the 5-prime portion of the CRYBB3 gene, which they designated beta-B3, by 5-prime RACE-PCR of lens RNA with primers based on the known … WebThe crystallin alpha A (CRYAA) and crystallin alpha B (CRYAB) act as specific molecular chaperones, which maintain proteins in large soluble aggregates. CRYAA and CRYAB are differentially expressed. Alpha A is expressed in the lens, and alpha B is expressed widely in many tissues and organs. cycloplegics and mydriatics
PDB-101: Molecule of the Month: Crystallins
WebAmino acid analyses of beta H and beta L and their corresponding subunit polypeptides demonstrated the close similarity of these crystallins. Trace element analyses indicated that both Ca and Mg are present in beta H and beta L crystallins and may be involved in maintaining the native quarternary structures of these proteins. Publication types WebCrystallin beta B2 (CRYbetaB2) overexpression in triple-negative breast cancers increases invasive cellular behaviors, tumor growth, IL6 production, immune cell chemoattraction, and the expression of metastasis-associated genes. Combined overexpression of both CRYbetaB2 and the pseudogene, CRYbetaB2P1, is found to suppress cell growth. WebThe alpha-crystallins are associated with a broad variety of neurological disorders. The beta/gamma-crystallin superfamily is characterized by four greek key motifs. The various N- and C-terminal extensions of the beta/gamma-crystallins are mainly responsible for their distinct biophysical and biochemical properties. cyclopithecus