Pttg1 transcription factor

Author: qsnj

August undefined, 2024

WebPTTG1 has transcriptional activity and exerts its function either by directly binding to DNA or by interacting with other proteins such as other transcription factors [13]. PTTG1 overexpression ... WebJun 21, 2024 · In contrast, the transcription factor and tumor suppressor Krüppel-like factor 6 (KLF6) has been found to act as a repressor by binding between −406 and −246 bp of the PTTG1 promoter [8,9]. PTTG1 is a highly hydrophilic multidomain protein located mainly in the cytoplasm as well as in the nucleus . PTTG1 has a functional C-terminal and a ...

Suppression of PTTG1 inhibits cell angiogenesis, migration

WebAug 16, 2013 · The aberrant expression of proto-oncogenes is involved in processes that are responsible for cellular proliferation and the inhibition of myeloid differentiation in acute … WebInterestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one transcription factor, Pttg1, showed significant differences between ... horizon credit card purchases

SP1-mediated transcriptional activation of PTTG1 regulates the ...

Webthat PTTG1 acts as a global transcription factor, and speciﬁcally modulates the G1/S-phase transition by interactingwithSp1,whichmayunderlieitstransform-ingactivity. Results WebSep 23, 2024 · Interestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one TF, Pttg1, showed significant differences between all three strains. The changes in Pttg1 expression were accompanied by consistent alterations in histone H3 lysine 4 trimethylation at Pttg1 transcription start … WebThe increased proliferation of activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and excessive extracellular matrix (ECM)-protein pro horizon credit card

Inflammation regulates long non-coding RNA-PTTG1-1:1 …

Pituitary Tumors: Role of Pituitary Tumor-Transforming Gene-1 (PTTG1 …

WebFIGURE 5 PTTG1 induces EMT via AKT signaling and Snail in breast cancer cells. A and B, transfection with siRNA targeting PTTG1 increased epithelial marker, E-cadherin, and decreased transcription factor Snail and mesenchymal markers, N-cadherin and vimentin in BT549 (A) and MDA-MB-231 (B), that express high levels of PTTG1. Detection of E ... WebWe selected the lncRNA PTTG1-1:1, also identified as MIR3142HG or ENST00000517927, as the most upregulated lncRNA. ... SiRNA-mediated knockdown of p65/NF-kB further … lord i know i\u0027ve been changedWebJan 1, 2013 · Human pituitary tumor transforming gene 1 (PTTG1) is an oncogenic transcription factor that is overexpressed in many malignancies, especially cancers with metastatic potential, while transgelin-2 (TAGLN2) is an actin-binding protein shown to be a tumor suppressor. However, the expression and clinical significance of PTTG1 and … lord i hope the day is good

"WebMar 12, 2007 · The results show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. This … " - Pttg1 transcription factor

Pttg1 transcription factor

Pituitary Tumor-Transforming Gene: Physiology and Implications …

WebFeb 16, 2024 · Some up-regulated transcription factors during the flowering period of petunia were identified through transcriptional analyses and further functionally … WebWell known as a transcription factors, KLF10 was involved in the regulation of a variety of genes in different tissues [18-20]. PTTG1 was a potential target of KLF10 in cardiac hypertrophy [6,21] but their relationship in MM …

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WebOct 20, 2008 · She showed that PTTG1 protein binds to the c-myc promoter near the transcription start site and forms a complex with the ubiquitous transcription activator upstream stimulating factor 1 (USF1). Mapping of PTTG1 protein showed the region between amino acids 60 and 118 as the PTTG-DNA binding domain. WebChromatin immunoprecipitation-on-chip study reveals that PTTG1 is a global transcription factor, which exerts its transcriptional activity either by directly binding to DNA or by …

WebJun 1, 2012 · Because ectopic expression of PTTG1 in normal breast MCF10A cells led to AKT activation, induction of transcription factor Snail, and acquisition of migratory and invasive properties, we next examined whether down-regulation of PTTG1 attenuates mesenchymal properties and thereby suppresses migration and invasiveness in breast …

WebResults show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. Data show that … WebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. The analysis of gene alteration, PTTG1 expression, prognostic function, and PTTG1-related …

WebThe encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) …

WebJun 29, 2024 · Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer … lord i know you are nearWebJul 28, 2024 · Overall, our findings indicate that PTTG1 is a glioma malignant factor that promotes angiogenesis, migration, invasion, and the evasion of apoptosis, and these roles … lord i lift my spirit to your spiritWebMar 27, 2024 · Keratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes survival of these cells under stress conditions. In a search for KGF-regulated … horizon credit card catalogWebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. Its overexpression occurs in a wide variety of human tumors including pituitary adenomas. Several factors and signalling pathways regulate pituitary PTTG1 expression, including estrogen, epidermal growth factor, octamer-binding transcription factor 1 and Rb/E2F1. horizon credit card bankWebFeb 24, 2024 · Multivariate analyses confirmed that PTTG1 expression was a factor of prognosis that is independent in terms of LUAD patients. Besides, PTTG1 methylation had a negative regulation on PTTG1, so PTTG1 had a high expressing level in LUAD tissues. ... (PTTG1), a ubiquitously expressed factor of transcription, is proven with the … lord i lift my friend to you casting crownsWebOct 30, 2024 · PTTG1 is also one of the inductive factors for the upregulated expression of pro-inflammatory TNF-α and oncogenic c-myc as well as the aggravated cell proliferation in hepatocellular carcinoma [9]. ... The promoter selective transcription factor SP1 regulates the expression of multiple genes and is involved in many cellular processes including ... horizon credit card online storeWebJul 28, 2024 · Overall, our findings indicate that PTTG1 is a glioma malignant factor that promotes angiogenesis, migration, invasion, and the evasion of apoptosis, and these roles may be related to the TGF-β/PI3K-AKT-mTOR pathway. Thus, the targeted inhibition of PTTG1 might be a novel therapeutic strategy and a potential diagnostic biomarker for … lord i know you are near lyrics