WebApr 7, 2024 · Nelson J. Chao, MD, MBAMichael Grunwald, MD. Panelists engage with a post hoc analysis of the REACH2 trial comparing early versus late treatment with ruxolitinib in patients with steroid-refractory acute Graft-Versus-Host Disease. EP: 1. Understanding Acute Graft-Versus-Host Disease. EP: 2. WebJul 12, 2024 · While ruxolitinib is overall effective, patients with higher-grade aGVHD, particularly if involving the gastrointestinal (GI) tract or liver, appear to be less likely to respond. 4, 7 Among patients enrolled in REACH2, 32% (n = 49) of patients randomized to ruxolitinib therapy for SR-aGVHD discontinued due to treatment ineffectiveness or ...
Post Hoc Analysis Review: REACH2 and Early vs. Late Treatment …
WebMay 7, 2024 · (Funded by Novartis; REACH2 ClinicalTrials.gov number, NCT02913261.). Ruxolitinib therapy led to significant improvements in efficacy outcomes, with a higher … WebOct 16, 2024 · Novartis expects to present the full REACH2 results at an upcoming medical congress and will initiate discussions with ex-U.S. regulatory authorities in 2024. Earlier … shree nagar news
REACH2: ruxolitinib for refractory aGvHD - Nature
WebApr 22, 2024 · About REACH2. REACH2 (NCT02913261), a randomized, open-label, multicenter Phase 3 study sponsored by Novartis and conducted in collaboration with and co-funded by Incyte , is evaluating the safety and efficacy of ruxolitinib compared with best available therapy in patients with steroid-refractory acute GVHD. WebNov 17, 2024 · REACH-2 randomized individuals to either ruxolitinib at a dose of 10 mg twice daily or best available therapy. In this trial, investigators had to declare what their … WebMar 25, 2024 · Results from the REACH2 trial showed an overall response rate (ORR) at Day 28 was superior in the ruxolitinib arm at 62.3% vs. 39.4% in the BAT arm (odds ratio [OR], 2.64; p<0.001) in patients with steroid refractory/dependent acute GVHD; and in those patients who maintained response at Day 56, the ORR in the Jakavi arm was 40% vs. 22% … shree nagar belgaum pin code